rs3765124
This is a protein-altering variant in the ADAMDEC1 gene.
▶Research that mentions this SNP (1)
▶Fine mapping and association studies in a candidate region for autism on chromosome 2q31–q32AssociationN=585Judith Conroy et al.(2009)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
A case-control study in a Russian population (285 type 1 diabetes patients, 300 controls) examining 58 SNPs across 47 genes involved in fibrogenesis, endothelial dysfunction, and inflammation. Seven SNPs showed significant association with T1D susceptibility: rs3765124 (ADAMDEC1 AA genotype, OR=1.79, p=0.004), rs1007856 (ITGB5 TT genotype, OR=1.67, p=0.015), rs20579 (LIG1 CC genotype, OR=1.86, p=0.004), rs12980602 (IFNL2 allele C, OR=1.49, p=0.029), rs4986819 (PARP4 allele C, OR=1.52, p=0.044), rs1143674 (ITGA4 GG genotype, OR=2.06, p=0.002), and rs679620 (MMP3 AA genotype, OR=2.03, p=0.008).
About ADAMDEC1
This encoded protein is thought to be a secreted protein belonging to the disintegrin metalloproteinase family. Its expression is upregulated during dendritic cells maturation. This protein may play an important role in dendritic cell function and their interactions with germinal center T cells. [provided by RefSeq, Jul 2008]
View all ADAMDEC1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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