rs3775296

A systematic literature review examining the association between toll-like receptor (TLR) single nucleotide polymorphisms and susceptibility to hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, including disease progression to liver cirrhosis and hepatocellular carcinoma. The review identifies polymorphisms in TLR2, TLR3, TLR4, TLR5, TLR7, TLR8, and TLR9 genes that affect viral susceptibility and disease outcomes, with mechanisms involving altered gene expression and immune signaling.

This comprehensive review examines genetic polymorphisms in innate immune response genes that influence susceptibility to respiratory syncytial virus (RSV) infection and disease severity in children. The paper discusses key genes including TLR2, TLR3, TLR4, RIG-I, IL-8, RANTES/CCL5, NF-κB, AP-1, and vitamin D receptor (VDR), highlighting how SNPs such as TLR4 Asp299Gly and Thr399Ile, RANTES -28C/G, IL-8 -251T, and VDR FokI polymorphisms are associated with increased RSV susceptibility or protection in pediatric populations.

A candidate gene association study of 714 healthy children examined associations between 148 SNPs in innate immunity genes (TLR, vitamin A and D receptors, RIG-I pathway, TRIM factors) and rubella vaccine-induced cytokine responses. Twenty-two significant associations (P = 0.002–0.048) were found, including rs3740996 (His43Tyr) and rs10838525 (Gln136Arg) in TRIM5 with TNFα and IL-2/GM-CSF responses, and rs5743305 in TLR3 with GM-CSF secretion.