rs3780901
This variant is located in the ALOX5 gene.
▶Research that mentions this SNP (1)
▶Association studies of ALOX5 and bone mineral density in healthy adultsAssociationN=2,915Foroud T. et al.(2008)· Osteoporosis International
Association study of 15 SNPs in ALOX5 with bone mineral density in 1,688 European American women, 512 African American women, and 715 European American men. Three SNPs showed nominal significance (p≤0.05) with lumbar spine or femoral neck BMD, but flanking SNPs in high linkage disequilibrium failed to replicate these associations, suggesting false positives. Authors conclude that variation in ALOX5 is unlikely to be a clinically significant risk factor for peak BMD.
About ALOX5
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
View all ALOX5 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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