rs3781637
This is a intron variant variant in the MTNR1B gene.
▶Research that mentions this SNP (2)
▶Functional polymorphisms of circadian positive feedback regulation genes and clinical outcome of Chinese patients with resected colorectal cancerReviewFeng Zhou et al.(2012)· Cancer
Handbook of Experimental Pharmacology (Volume 217) providing comprehensive review of circadian clock biology and its role in health and disease. Discusses molecular mechanisms of circadian regulation, circadian control of metabolism, sleep, hormones, and behavior, and applications to pharmacotherapy including cancer chronotherapy. Reviews genetic variants in circadian genes (CLOCK rs1801260 and rs4580704, MTNR1A rs2119882, MTNR1B rs3781637) associated with metabolic traits and disease susceptibility, and circadian clock gene mutations linked to cancer risk and metabolic disorders.
▶Fasting Glucose GWAS Candidate Region Analysis Across Ethnic Groups in the Multiethnic Study of Atherosclerosis (MESA)AssociationN=5,550Rasmussen-Torvik LJ et al.(2012)· Genetic Epidemiology
This study examined genetic variants associated with fasting glucose from previously identified GWAS loci in four ethnic groups (Caucasian, African American, Hispanic, and Chinese descent) from the Multi-Ethnic Study of Atherosclerosis (MESA). The analysis focused on three gene regions (MTNR1B, GCK, and G6PC2) and found that rs10830963 in MTNR1B and rs4607517 in GCK demonstrated consistent magnitude of association with fasting glucose across ethnic groups (p = 1.29E-12 and p = 1.0E-7, respectively in meta-analysis), with effect sizes ranging from 1.22-1.66 mg/dl and -1.19 to -1.06 mg/dl respectively.
About MTNR1B
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008]
View all MTNR1B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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