MTNR1B

melatonin receptor 1B

Summary

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008]

Known Variants39 total

rsidPosition (GRCh37)AllelesClassClinVar
rs475342611:92,701,596T/Cupstream gene variant
rs75152143111:92,702,923G/Auncertain significance
rs121796616811:92,702,925G/Auncertain significance
rs819255211:92,702,962A/Gbenign
rs156517758011:92,702,977G/Alikely benign
rs38790677911:92,703,015G/Crisk factor
rs14180475211:92,703,070T/Grisk factor
rs1280429111:92,705,307C/Tintron variant
rs1083096311:92,708,710C/Gintron variant
rs378163811:92,713,507G/C
rs378163711:92,713,770T/Cintron variant
rs18234937611:92,714,673C/Trisk factor
rs76204310111:92,714,702G/Auncertain significance
rs14970389711:92,714,725C/Tlikely benign
rs76288318511:92,714,738G/Auncertain significance
rs14489846411:92,714,767C/Tbenign
rs74589668911:92,714,791C/Guncertain significance
rs77158263611:92,714,811A/Guncertain significance
rs75182458611:92,714,847G/Auncertain significance
rs14098433511:92,714,893C/Tlikely benign
rs185810874411:92,714,925G/Tuncertain significance
rs37204372611:92,714,935G/Tuncertain significance
rs37112389511:92,714,982C/Alikely benign
rs134784987911:92,714,990A/Guncertain significance
rs19969499811:92,715,032G/Tuncertain significance
rs6174713911:92,715,117A/Gbenign
rs249591239411:92,715,135G/Tuncertain significance
rs77848062111:92,715,156T/Cuncertain significance
rs37017530911:92,715,205C/Tlikely benign
rs14185504011:92,715,221C/Guncertain significance
rs124432135911:92,715,236C/Tuncertain significance
rs6174196511:92,715,300A/Guncertain significance
rs18491768211:92,715,312A/Crisk factor
rs37398193611:92,715,326C/Guncertain significance
rs19224615311:92,715,335C/Tuncertain significance
rs37712533711:92,715,363C/Tbenign
rs20005534411:92,715,384G/Auncertain significance
rs76045905311:92,715,396C/Tuncertain significance
rs156244411:92,715,849G/A3 prime UTR variant

Gene information from NCBI Gene. Variant classifications from ClinVar.