rs3781638
This variant is located in the MTNR1B gene.
▶Research that mentions this SNP (1)
▶Association of osteoporosis with genetic variants of circadian genes in Chinese geriatricsAssociationN=597Li Y. et al.(2016)· Osteoporosis International
This cross-sectional candidate gene study examined 14 tag SNPs in 7 circadian genes for association with osteoporosis risk in 597 Chinese geriatric subjects. CRY2 rs2292910 showed protective effects (AC genotype OR=0.647, p=0.044), while MTNR1B rs3781638 showed increased risk (GG genotype OR=2.058, p=0.044). The findings suggest circadian gene variants may influence bone mineral density and osteoporosis susceptibility.
About MTNR1B
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008]
View all MTNR1B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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