rs3782116
This is a intron variant variant in the SIRT3 gene.
▶Research that mentions this SNP (1)
▶The dominant model analysis of Sirt3 genetic variants is associated with susceptibility to tuberculosis in a Chinese Han populationAssociationN=2,434Tao Wu et al.(2020)· Molecular Genetics and Genomics
A case-control study of 900 TB patients and 1534 controls in a Chinese Han population examined five SIRT3 gene SNPs for association with tuberculosis susceptibility. The rs3782118 minor allele (A) showed decreased TB risk (OR 0.787, p=0.026 under dominant model), and haplotype AGAAG was associated with increased TB risk (OR 1.159, p=0.023). Stratification analysis found the protective effect of rs3782118 was particularly pronounced in females (OR 0.678, p=0.016).
About SIRT3
SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019]
View all SIRT3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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