rs3790844

This variant is located in the NR5A2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

pancreatic carcinoma

Klein AP et al. “Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.” Nature Communications 9(1):556 (2018)

Allele A

OR 1.23

p 8.0e-16

N 21,536

Meta-analysisLarge GWAS

European

Petersen GM et al. “A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.” Nature Genetics 42(3):224-8 (2010)

Allele A

OR 1.30

p 2.0e-10

N 7,785

Large GWAS

multi-ancestry

About NR5A2

The protein encoded by this gene is a DNA-binding zinc finger transcription factor and is a member of the fushi tarazu factor-1 subfamily of orphan nuclear receptors. The encoded protein is involved in the expression of genes for hepatitis B virus and cholesterol biosynthesis, and may be an important regulator of embryonic development. [provided by RefSeq, Jun 2016]

View all NR5A2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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