rs3796863
This variant is located in the CD38 gene.
▶Research that mentions this SNP (1)
▶An interaction between oxytocin and a genetic variation of the oxytocin receptor modulates amygdala activity toward direct gaze: evidence from a pharmacological imaging genetics studyFunctionalN=55Christian Montag et al.(2013)· European Archives of Psychiatry and Clinical Neuroscience
A pharmacological imaging genetics study examining the interaction between intranasal oxytocin administration and OXTR gene variants on amygdala reactivity to direct gaze in 55 healthy males. The rs401015 CT heterozygous carriers showed significantly increased amygdala activation to direct gaze under oxytocin compared to TT homozygotes, while rs2268498 and rs180789 showed no significant interaction effects with oxytocin on gaze processing.
About CD38
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
View all CD38 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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