rs37973
This variant is located in the GLCCI1 gene.
▶ClinVar annotation
▶Research that mentions this SNP (1)
▶Polymorphisms in the glucocorticoid receptor gene and in the glucocorticoid-induced transcript 1 gene are associated with disease activity and response to glucocorticoid bridging therapy in rheumatoid arthritisAssociationN=138Quax RA et al.(2015)· Rheumatology International
This prospective study of 138 patients with rheumatoid arthritis (RA) examined associations between polymorphisms in the glucocorticoid receptor (GR) gene and the glucocorticoid-induced transcript 1 gene (GLCCI1) with baseline disease activity and response to glucocorticoid bridging therapy. Carriers of GR polymorphisms and GLCCI1 variants associated with decreased GC sensitivity (9β-G, ER22/23EK-A/A, GLCCI1-T alleles) showed higher baseline disease activity. The GLCCI1 gene minor allele (rs37972 T allele) was associated with significantly lower clinical response to GC therapy specifically in male RA patients, suggesting gender-specific pharmacogenetic effects.
About GLCCI1
This gene encodes a protein of unknown function. Expression of this gene is induced by glucocorticoids and may be an early marker for glucocorticoid-induced apoptosis. Single nucleotide polymorphisms in this gene are associated with a decreased response to inhaled glucocorticoids in asthmatic patients. [provided by RefSeq, Feb 2012]
View all GLCCI1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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