rs3803277

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

bipolar I disorder

Mullins N et al. “Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.” Nature Genetics 53(6):817-829 (2021)
Allele C
OR 1.07
p 2.0e-8
N 475,038
Large GWAS
European
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Research that mentions this SNP (1)

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Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease
AssociationN=13,135Themistocles L. Assimes et al.(2008)· Human Genetics

Case-control and replication study examining ALOX5 and ALOX5AP polymorphisms and coronary artery disease (CAD) risk in 1,552 CAD cases and 1,583 controls from the ADVANCE study and ARIC cohort. A nominally significant association was detected between rs12762303 (ALOX5 promoter) and CAD in white/European subjects (OR=1.32 per minor allele; P=0.002), but this association could not be reproduced in the ARIC replication study (HR=1.08; P=0.2). No significant associations were observed for other SNPs tested in either gene, leading to the conclusion that common allelic variation in ALOX5 and ALOX5AP does not provide strong evidence for CAD susceptibility.

Traits studied:Carotid intima media thicknessCoronary artery diseaseMyocardial infarction
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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