rs3820888
This is a regulatory region variant variant in the SPATS2L gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
atrial fibrillation
Yuan S et al. “Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation.” Nature Communications 16(1):6426 (2025)
Allele T
OR 0.05
p 6.0e-45
N 1,840,341
Large GWAS
European
Miyazawa K et al. “Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction.” Nature Genetics 55(2):187-197 (2023)
Allele T
OR 0.07
p 9.0e-31
N 2,339,188
Large GWAS
multi-ancestry
Nielsen JB et al. “Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.” Nature Genetics 50(9):1234-1239 (2018)
Allele T
OR 1.07
p 6.0e-24
N 1,030,836
Large GWAS
European
heart failure
Rasooly D et al. “Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure.” Nature Communications 14(1):3826 (2023)
Allele T
OR 0.03
p 1.0e-9
N 1,279,610
Large GWAS
European
Enzan N et al. “Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population.” Nature Communications 16(1):9680 (2025)
Allele T
OR 0.03
p 4.0e-8
N 1,672,415
Large GWAS
multi-ancestry
About SPATS2L
Enables RNA binding activity. Located in cytosol; nucleolus; and nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
View all SPATS2L variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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