rs3851357

This variant is located in the PLCH1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

childhood trauma measurement

Warrier V et al. “Gene-environment correlations and causal effects of childhood maltreatment on physical and mental health: a genetically informed approach.” The Lancet. Psychiatry 8(5):373-386 (2021)

Allele A

OR 0.03

p 3.0e-8

N 185,414

Large GWAS

European

About PLCH1

PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 [PubMed 15702972]).[supplied by OMIM, Jun 2009]

View all PLCH1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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