rs3887925

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

type 2 diabetes mellitus

Suzuki K et al. “Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.” Nature 627(8003):347-357 (2024)

Allele T

OR —

p 6.0e-44

N 2,535,601

Large GWAS

multi-ancestry

Elashi AA et al. “Genome-wide association study and trans-ethnic meta-analysis identify novel susceptibility loci for type 2 diabetes mellitus.” Bmc Medical Genomics 17(1):115 (2024)

Allele T

OR 0.05

p 5.0e-21

N 6,710,881

Meta-analysisLarge GWAS

multi-ancestry

Vujkovic M et al. “Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis.” Nature Genetics 52(7):680-691 (2020)

Allele T

OR 0.04

p 1.0e-25

N 1,407,282

Meta-analysisLarge GWAS

multi-ancestry

Mahajan A et al. “Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.” Nature Genetics 50(11):1505-1513 (2018)

Allele T

OR 1.07

p 3.0e-22

N 898,130

Large GWAS

European

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele T

OR 0.05

p 3.0e-17

N 667,504

Large GWAS

multi-ancestry

Xue A et al. “Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.” Nature Communications 9(1):2941 (2018)

Allele T

OR 0.05

p 2.0e-9

N 659,316

Large GWAS

multi-ancestry

Huerta-Chagoya A et al. “Rare variant analyses in 51,256 type 2 diabetes cases and 370,487 controls reveal the pathogenicity spectrum of monogenic diabetes genes.” Nature Genetics 56(11):2370-2379 (2024)

Allele T

OR 0.07

p 3.0e-20

N 421,743

Large GWAS

multi-ancestry

Mahajan A et al. “Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.” Nature Genetics 54(5):560-572 (2022)

Allele T

OR 0.06

p 3.0e-23

N 251,740

Large GWAS

European

Ishigaki K et al. “Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases.” Nature Genetics 52(7):669-679 (2020)

Allele T

OR 1.05

p 4.0e-8

N 210,865

Large GWAS

East Asian

Drugs used in diabetes use measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele T

OR 0.05

p 1.0e-11

N 484,639

Large GWAS

multi-ancestry

diabetes mellitus

Schoeler T et al. “Participation bias in the UK Biobank distorts genetic associations and downstream analyses.” Nature Human Behaviour 7(7):1216-1227 (2023)

Allele C

OR 0.00

p 8.0e-9

N 283,227

Major Consortium StudyLarge GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

rs3887925

GWAS Catalog Trait Associations (3)

type 2 diabetes mellitus

Drugs used in diabetes use measurement

diabetes mellitus

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