rs3899697

A genome-wide association study (GWAS) of 226 Japanese women with cervical cancer and 186 controls identified 89 SNPs with p-value < 10^-4, including rs997363 (p=1.23×10^-6, OR=1.99), rs7780883 (p=2.49×10^-6, OR=3.28), and rs6726538 (p=2.76×10^-6, OR=0.52), but no SNPs met genome-wide significance threshold after multiple-testing correction. Two SNPs, rs621310 and rs11653282, showed weak associations in replication analysis. The study suggests that HPV-associated cervical cancer susceptibility in Japanese women may involve multiple genetic variants with small individual effects, or that larger sample sizes are needed to detect true associations.