rs3916765

This is a upstream gene variant variant in the LOC102725019 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

acute myeloid leukemia

Lin WY et al. “Genome-wide association study identifies susceptibility loci for acute myeloid leukemia.” Nature Communications 12(1):6233 (2021)
Allele G
OR 1.72
p 2.0e-10
N 9,801
Large GWAS
European
Ranasinghe D et al. “Common variation at 1q23.3, 2p23.3, 2q33.3, and 2p21 influences risk of acute myeloid leukemia.” Blood (2026)
Allele G
OR 1.56
p 1.0e-9
N 14,521
Large GWAS
European
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Research that mentions this SNP (1)

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Genome‐wide association study of rheumatoid arthritis in Koreans: Population‐specific loci as well as overlap with European susceptibility loci
AssociationN=2,002Jan Freudenberg et al.(2011)· Arthritis &amp; Rheumatism

This study applied Bayesian epistasis association mapping (BEAM/BEAM2) methods to genome-wide association studies data from the Welcome Trust Case Control Consortium (WTCCC) to identify high-order SNP interactions in rheumatoid arthritis. The analysis identified 319 high-order epistatic interactions across the genome, with many validated using data from the North American Rheumatoid Arthritis Consortium (NARAC). Key findings include inter-chromosomal interactions primarily on chromosomes 1, 3, 6, and 9, with enriched GO terms implicating synapse, calcium ion binding, and membrane pathways.

Traits studied:Rheumatoid arthritis
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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