rs3917010
This is a intron variant variant in the VCAM1 gene.
▶Research that mentions this SNP (1)
▶Genetic predictors of depressive symptoms in cardiac patientsAssociationN=977Jeanne M. McCaffery et al.(2009)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
A candidate gene association study of 977 French-Canadian cardiac patients examining genetic predictors of depressive symptoms. Over 700 SNPs in 59 genes related to inflammation, platelet aggregation, endothelial function, and fatty acid metabolism pathways were genotyped. rs216873 in the von Willebrand factor (VWF) gene was significantly associated with Beck Depression Inventory-II scores after correction for multiple comparisons (p = 7.4 × 10⁻⁵; odds ratio = 1.51, 95% CI: 1.17-1.94 for the T allele). Several additional SNPs showed suggestive association (p < 0.01) in genes related to endothelial dysfunction including VCAM1, CACNA1C, and HTR2A.
About VCAM1
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]
View all VCAM1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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