rs3917225
This is a intron variant variant in the IL1R1 gene.
▶Research that mentions this SNP (1)
▶Association between the IL1R2 rs2072472 polymorphism and high‐altitude pulmonary edema riskAssociationN=568Tianbo Jin et al.(2019)· Molecular Genetics & Genomic Medicine
A case-control study of 265 HAPE cases and 303 controls in a Chinese Han population investigated associations between 11 SNPs in IL1R1 and IL1R2 genes and high-altitude pulmonary edema (HAPE) risk. The rs2072472 variant in IL1R2 was significantly associated with decreased HAPE risk (OR = 0.73, 95% CI = 0.55-0.97, p = 0.033 in allele model; OR = 0.66, 95% CI = 0.49-0.90, p = 0.009 in log-additive model adjusted for age and gender), suggesting IL1R2 polymorphisms may play a protective role in HAPE susceptibility.
About IL1R1
This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]
View all IL1R1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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