rs3939286

This is a intergenic variant variant.

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

asthma

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.13
p 2.0e-66
N 394,626
Large GWAS
European

proteoglycan 3 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.06
p 6.0e-25
N 47,745
Large GWAS
European

seasonal allergic rhinitis

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.08
p 7.0e-17
N 394,626
Large GWAS
European

Nasal Cavity Polyp

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.27
p 7.0e-15
N 394,626
Large GWAS
European
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Research that mentions this SNP (1)

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The Impact of Interleukin (IL)-33 Gene Polymorphisms and Environmental Factors on Risk of Asthma in the Iranian Population
AssociationN=426Mojdeh Matloubi et al.(2020)· Lung

A case-control study of 126 asthma patients and 300 controls in the Iranian population examined IL-33 gene polymorphisms rs1342326 and rs3939286. The C/C genotype of rs1342326 (OR 2.50, 95% CI 1.33-4.69) and A/A genotype of rs3939286 (OR 2.18, 95% CI 1.05-4.52) were significantly associated with increased asthma risk. rs1342326 associated with atopic, mild, and adult-onset asthma with elevated eosinophil levels, while rs3939286 associated with non-atopic, moderate-to-severe, and childhood-onset asthma.

Traits studied:Adult-onset asthmaAsthmaAtopic asthmaChildhood-onset asthmaMild asthmaModerate-to-severe asthmaNon-atopic asthma
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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