rs4076128
This is a regulatory region variant variant in the ALOX5AP gene.
▶Research that mentions this SNP (1)
▶Associations between arachidonic acid metabolism gene polymorphisms and prostate cancer riskAssociationN=1,170Amirian ES et al.(2011)· The Prostate
Case-control study of 585 prostate cancer cases and 585 controls examining 14 SNPs in arachidonic acid metabolism genes. LTA4H rs1978331 TC genotype was protective (OR=0.66, 95% CI: 0.50-0.86). PTGES2 rs10987883 GG genotype showed increased prostate cancer risk in non-obese individuals (OR=2.53, 95% CI: 0.99-6.55). Results suggest SNPs in AA pathway genes may influence prostate cancer susceptibility, with obesity potentially modifying these associations.
About ALOX5AP
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
View all ALOX5AP variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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