rs4076452
This is a intron variant variant in the LINC02210-CRHR1 gene.
▶Research that mentions this SNP (1)
▶Association of CRHR1 and CRHR2 with major depressive disorder and panic disorder in a Japanese populationAssociationN=638Yoshinobu Ishitobi et al.(2012)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
This Japanese case-control study examined 12 SNPs in CRHR1 and CRHR2 genes in 173 major depressive disorder (MDD) patients, 180 panic disorder (PD) patients, and 285 healthy controls. SNP rs110402 in CRHR1 showed association with MDD (p=0.001, OR=1.81), as did rs242924 in CRHR1 for both MDD (p=0.013) and PD (p=0.022, OR=1.55). SNP rs3779250 in CRHR2 showed strong association with MDD (p=1.75e-11, OR=2.83). Haplotype analyses identified T-A-T-G-G and T-A haplotypes in CRHR1 associated with MDD, and C-C haplotype in CRHR2 associated with PD.
About LINC02210-CRHR1
This locus represents naturally occurring readthrough transcription between neighboring genes CRHR1-IT1, CRHR1 intronic transcript 1 (Gene ID: 147081) and CRHR1, corticotropin releasing hormone receptor 1 (Gene ID: 1394) on chromosome 17. The readthrough transcript encodes a protein that shares sequence identity with the product of the CRHR1 gene. [provided by RefSeq, Dec 2016]
View all LINC02210-CRHR1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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