rs41265094
This variant is located in the IRS1 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
appendicular lean mass
Pei YF et al. “The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank study.” Communications Biology 3(1):608 (2020)
Allele C
OR 0.06
p 1.0e-17
N 450,243
Major Consortium StudyLarge GWAS
European
▶ClinVar annotation
Likely Benign★★★☆
6 submitters2 publicationsnot specified; Type 2 diabetes mellitus; not provided
View on ClinVar →About IRS1
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]
View all IRS1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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