rs41268928
This variant is located in the RNF5 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
sRAGE measurement
Maruthur NM et al. “Genetics of Plasma Soluble Receptor for Advanced Glycation End-Products and Cardiovascular Outcomes in a Community-based Population: Results from the Atherosclerosis Risk in Communities Study.” Plos One 10(6):e0128452 (2015)
Allele C
OR 0.69
p 3.0e-16
N 2,318
CohortLarge GWAS
multi-ancestry
mean arterial pressure
Pozarickij A et al. “Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults.” Nature Communications 15(1):6265 (2024)
Allele G
OR 0.57
p 1.0e-13
N 100,453
Large GWAS
East Asian
About RNF5
The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. [provided by RefSeq, Jul 2008]
View all RNF5 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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