rs41272321

This is a protein-altering variant in the ACAD11 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

hemoglobin measurement

Oskarsson GR et al. “Predicted loss and gain of function mutations in ACO1 are associated with erythropoiesis.” Communications Biology 3(1):189 (2020)

Allele G

OR —

β 0.023

p 5.0e-11

N 684,122

Large GWAS

European

fetal genotype effect measurement, protein measurement, CCL21 measurement

Traglia M et al. “Cross-genetic determination of maternal and neonatal immune mediators during pregnancy.” Genome Medicine 10(1):67 (2018)

Allele G

OR 0.20

p 3.0e-10

N 764

Small GWAS

multi-ancestry

About ACAD11

This gene encodes an acyl-CoA dehydrogenase enzyme with a preference for carbon chain lengths between 20 and 26. Naturally occurring read-through transcription occurs between the upstream gene NPHP3 (nephronophthisis 3 (adolescent)) and this gene. [provided by RefSeq, Aug 2015]

View all ACAD11 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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