rs41277978

This is a protein-altering variant in the AIFM2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

BMI-adjusted waist-hip ratio

Akbari P et al. “Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes.” Nature Communications 13(1):4844 (2022)

Allele A

OR 0.07

p 4.0e-11

N 618,375

Large GWAS

multi-ancestry

Pulit SL et al. “Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.” Human Molecular Genetics 28(1):166-174 (2019)

Allele A

OR 0.07

p 5.0e-10

N 379,501

Meta-analysisLarge GWAS

European

About AIFM2

This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. [provided by RefSeq, Nov 2010]

View all AIFM2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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