rs41289586

This is a variant in the ANO10 gene that changes a arginine to an histidine.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

central nervous system non-hodgkin lymphoma

Labreche K et al. “A genome-wide association study identifies susceptibility loci for primary central nervous system lymphoma at 6p25.3 and 3p22.1: a LOC Network study.” Neuro-oncology 21(8):1039-1048 (2019)

Allele T

OR 3.82

p 2.0e-8

N 1,609

Large GWAS

European

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ClinVar annotation

Likely Benign★★★☆

8 submitters10 publications

Autosomal recessive spinocerebellar ataxia 10; not specified

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About ANO10

The transmembrane protein encoded by this gene belongs to the anoctamin family of calcium-activated chloride channels, also known as the transmembrane 16 family. The encoded protein contains eight transmembrane domains with cytosolic N- and C-termini. Defects in this gene may cause autosomal recessive spinocerebellar ataxia-10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

View all ANO10 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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