rs41299076

This is a protein-altering variant in the MAGEC1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Hodgkins lymphoma

Osman Y et al. “Functional multigenic variations associated with hodgkin lymphoma.” International Journal of Laboratory Hematology 43(6):1472-1482 (2021)

Allele T

OR —

β 0.025

p 7.0e-11

N 97

Small GWAS

Greater Middle Eastern (Middle Eastern, North African or Persian)

About MAGEC1

This gene is a member of the melanoma antigen gene (MAGE) family. The proteins of this family are tumor-specific antigens that can be recognized by autologous cytolytic T lymphocytes. This protein contains a large number of unique short repetitive sequences in front of the MAGE-homologous sequence, and therefore is about 800 aa longer than the other MAGE proteins. [provided by RefSeq, Jul 2008]

View all MAGEC1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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