rs41315284

This is a protein-altering variant in the ARHGEF16 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

glomerular filtration rate

Loeb GB et al. “Variants in tubule epithelial regulatory elements mediate most heritable differences in human kidney function.” Nature Genetics 56(10):2078-2092 (2024)

Allele G

OR 0.11

p 2.0e-14

N 406,504

Large GWAS

European

cystatin C measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele G

OR 0.13

p 1.0e-13

N 355,752

Major Consortium StudyLarge GWAS

multi-ancestry

level of creatine kinase U-type, mitochondrial in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.30

p 7.0e-13

N 47,745

Large GWAS

European

About ARHGEF16

Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and protein-lipid interactions. [provided by RefSeq, Jul 2008]

View all ARHGEF16 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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