rs4149406

This is a downstream gene variant variant in the SULT1A2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

intelligence

Schoeler T et al. “Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.” Nature Communications 16(1):4524 (2025)
Allele A
OR 0.03
p 3.0e-20
N 254,641
Large GWAS
European
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Research that mentions this SNP (1)

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Common variants in BDNF, FAIM2, FTO, MC4R, NEGR1, and SH2B1 show association with obesity‐related variables in Spanish Roma population
AssociationN=3,210Alaitz Poveda et al.(2014)· American Journal of Human Biology

This study performed fine mapping of the obesity-associated region chr16p11.2 by screening the coding regions of APOBR, SULT1A1, SULT1A2, and TUFM genes in 95 extremely obese children and adolescents. Two APOBR variants, rs180743 (p.Pro428Ala) and rs3833080 (p.Gly369_Asp370del9), showed significant association with obesity (p=0.002 and p=0.003 respectively) in case-control analysis of 1,873 obese cases versus 435 lean controls, with odds ratios of 1.27 and 1.25 per allele.

Traits studied:Body mass indexExtreme obesityObesity
PubMedDOIMetascience Observatory

About SULT1A2

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Two alternatively spliced variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]

View all SULT1A2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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