rs422068
▶GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
heart rate
Eppinga RN et al. “Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.” Nature Genetics 48(12):1557-1563 (2016)
Allele C
OR 0.73
p 2.0e-100
N 134,251
Large GWAS
multi-ancestry
Ramírez J et al. “Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system.” Nature Communications 9(1):1947 (2018)
Allele C
OR 0.71
p 1.0e-26
N 67,062
Large GWAS
European
atrial fibrillation
Miyazawa K et al. “Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction.” Nature Genetics 55(2):187-197 (2023)
Allele C
OR 0.05
p 1.0e-13
N 2,339,188
Large GWAS
multi-ancestry
Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)
Allele C
OR 0.01
p 8.0e-10
N 1,486,094
Large GWAS
European
Nielsen JB et al. “Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.” Nature Genetics 50(9):1234-1239 (2018)
Allele C
OR 1.04
p 4.0e-10
N 1,030,836
Large GWAS
European
heart rate response to exercise
Cai L et al. “Causal associations between cardiorespiratory fitness and type 2 diabetes.” Nature Communications 14(1):3904 (2023)
Allele T
OR 0.25
p 1.0e-11
N 69,416
Large GWAS
European
heart rate response to recovery post exercise
Diamant N et al. “Deep learning on resting electrocardiogram to identify impaired heart rate recovery.” Cardiovascular Digital Health Journal 3(4):161-170 (2022)
Allele T
OR 0.20
p 2.0e-10
N 43,722
Major Consortium StudyLarge GWAS
European
descending aorta diameter
Pirruccello JP et al. “The Genetic Determinants of Aortic Distention.” Journal of the American College of Cardiology 81(14):1320-1335 (2023)
Allele T
OR 0.04
p 7.0e-10
N 39,893
Large GWAS
European, NR
Pirruccello JP et al. “Deep learning enables genetic analysis of the human thoracic aorta.” Nature Genetics 54(1):40-51 (2022)
Allele T
OR 0.04
p 1.0e-9
N 34,532
Large GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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