rs4237
This is a upstream gene variant variant in the PITHD1 gene.
▶Research that mentions this SNP (1)
▶Evaluation of common variants in CNR2 gene for bone mineral density and osteoporosis susceptibility in postmenopausal women of Han ChineseAssociationN=3,121Zhang C. et al.(2015)· Osteoporosis International
This case-control study evaluated 39 SNPs in the CNR2 gene for association with bone mineral density (BMD) and osteoporosis in 1,032 postmenopausal osteoporosis patients and 2,089 healthy Han Chinese controls. Two SNPs (rs4237 and rs2501431) were significantly associated with osteoporosis, with rs4237 showing p=0.000515 and rs2501431 showing p=0.000441, both with odds ratios around 1.2. Haplotype analysis identified five haplotypes with significant associations, particularly HAP9 which showed 4-fold increased frequency in cases (p<0.001).
About PITHD1
Involved in positive regulation of DNA-templated transcription and positive regulation of megakaryocyte differentiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
View all PITHD1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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