rs4240671
This is a regulatory region variant variant in the XKR6 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
social inhibition quality, attention deficit hyperactivity disorder, substance abuse
▶Research that mentions this SNP (1)
▶“The Heidelberg Five” personality dimensions: Genome‐wide associations, polygenic risk for neuroticism, and psychopathology 20 years after assessmentAssociationN=481Urs Heilbronner et al.(2021)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
This study evaluated the use of polygenic scores (PGS) based on 10 top SNPs from European GWAS meta-analysis of antisocial behavior to predict liability to severe criminal behavior (homicide) in a Russian cohort of 227 offenders and 254 controls. A PGS based on rs993137 (CADM2), rs458806 (REV3L), rs11720703 (FOXP1), and rs1476535 (FOXP2) explained 1.5% of variance in liability to antisocial behavior, while the combined genetic model with social factors (traumatic brain injury, chronic disease, tobacco smoking) explained up to 21.2% of variance (p = 2 × 10⁻¹³), demonstrating that social factors have substantially greater predictive impact than genetic variants alone.
About XKR6
Predicted to be involved in apoptotic process involved in development; engulfment of apoptotic cell; and phosphatidylserine exposure on apoptotic cell surface. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all XKR6 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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