rs4248154
This is a synonymous variant in the MUC22 gene — it does not change the protein's amino acid sequence.
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
platelet count
Kachuri L et al. “Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia.” American Journal of Human Genetics 108(10):1823-1835 (2021)
Allele C
OR —
p 5.0e-19
N 235,256
Large GWAS
European
Graves disease
Nakabayashi K et al. “Identification of independent risk loci for Graves' disease within the MHC in the Japanese population.” Journal of Human Genetics 56(11):772-8 (2011)
Allele C
OR 1.38
p 1.0e-13
N 3,837
Large GWAS
East Asian
body height
Schoeler T et al. “Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.” Nature Communications 16(1):4524 (2025)
Allele C
OR 0.01
p 2.0e-13
N 405,540
Large GWAS
European
Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)
Allele C
OR 0.01
p 2.0e-12
N 5,314,291
Large GWAS
European, Hispanic or Latin American, East Asian, African unspecified, South Asian
prostate carcinoma
Rashkin SR et al. “Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts.” Nature Communications 11(1):4423 (2020)
Allele T
OR 1.11
p 4.0e-8
N 421,142
Large GWAS
European
About MUC22
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all MUC22 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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