rs425535

This is a synonymous variant in the CXCL5 gene — it does not change the protein's amino acid sequence.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

CXCL5 measurement

Gudjonsson A et al. “A genome-wide association study of serum proteins reveals shared loci with common diseases.” Nature Communications 13(1):480 (2022)

Allele T

OR 0.77

p 6.0e-236

N 5,366

Large GWAS

European

Enroth S et al. “Strong effects of genetic and lifestyle factors on biomarker variation and use of personalized cutoffs.” Nature Communications 5:4684 (2014)

Allele T

OR 0.86

p 4.0e-26

N 970

Small GWAS

C-X-C motif chemokine 5 measurement

Surapaneni A et al. “Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension.” Kidney International 102(5):1167-1177 (2022)

Allele C

OR 0.61

p 3.0e-21

N 466

Small GWAS

African American or Afro-Caribbean

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Research that mentions this SNP (1)

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CXCL5 Gene Polymorphism Association with Diabetes Mellitus

AssociationN=332Shirin Hasani Ranjbar et al.(2008)· Molecular Diagnosis & Therapy

This case-control study examined the association between the CXCL5 -156G>C promoter polymorphism (rs352046) and type 2 diabetes mellitus in an Iranian population of 230 diabetic patients and 102 healthy controls. The C allele was significantly associated with increased diabetes risk (OR=1.72, p=0.01), with carriers of G/C or C/C genotypes showing 2.17-fold higher risk compared to G/G (p=0.004). No association was found between this polymorphism and diabetic complications.

Traits studied:Diabetic nephropathyDiabetic neuropathyDiabetic retinopathyType 2 diabetes mellitus

DOI Metascience Observatory

About CXCL5

This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]