rs4263397
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
protein measurement
▶Research that mentions this SNP (1)
▶The Alzheimer disease BIN1 locus as a modifier of GBA-associated Parkinson diseaseAssociationN=154Gan-Or Z. et al.(2015)· Journal of Neurology
This genome-wide association study identifies BIN1 rs13403026 as a genetic modifier of age at motor symptom onset in GBA-associated Parkinson disease. In 154 patients with GBA mutations (79 with p.N370S in discovery, 113 with mild mutations in validation, 41 with severe mutations in replication), the minor allele of rs13403026 was associated with approximately 12.4 years later onset in the combined cohort (p=0.0001), 10.7 years later in mild mutation carriers (p=0.005), and 17.1 years later in severe mutation carriers (p=0.01). The finding suggests that BIN1 locus variants, previously associated with Alzheimer disease, may also modify Parkinson disease onset in GBA mutation carriers.
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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