rs4271002
This variant is located in the NAT2 gene.
▶Research that mentions this SNP (1)
▶An exploratory case‐only analysis of gene‐hazardous air pollutant interactions and the risk of childhood medulloblastomaAssociationN=98Lupo PJ et al.(2012)· Pediatric Blood & Cancer
A case-only study of 98 children with medulloblastoma/PNET examining gene-environment interactions between chlorinated solvent exposure and detoxification/DNA repair genotypes. Found 11 significant interactions; after multiple comparison correction, only the interaction between high trichloroethylene exposure and OGG1 rs293795 remained significant (OR = 9.24, 95% CI: 2.24-38.24). Two additional borderline significant interactions identified: OGG1 rs159150 with trichloroethylene (OR = 6.50) and NAT1 rs13253389 with vinyl chloride (OR = 0.05, protective).
About NAT2
This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second polymorphic arylamine N-acetyltransferase gene (NAT1), is located near this gene (NAT2). [provided by RefSeq, Sep 2019]
View all NAT2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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