rs4311394

This variant is located in the ARL15 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

adiponectin measurement

Richards JB et al. “A genome-wide association study reveals variants in ARL15 that influence adiponectin levels.” Plos Genetics 5(12):e1000768 (2009)
Allele G
OR 0.96
p 3.0e-8
N 8,531
Large GWAS
European
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Research that mentions this SNP (1)

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Relationship between ADIPOQ gene, circulating high molecular weight adiponectin and albuminuria in individuals with normal kidney function: evidence from a family-based study
AssociationN=634Menzaghi C. et al.(2011)· Diabetologia

Family-based study of 634 non-diabetic individuals examining the ADIPOQ gene and albuminuria. rs17300539 in the ADIPOQ promoter was significantly associated with albumin-creatinine ratio (ACR, p=0.0027) and explained 4% of variance, and with HMW adiponectin levels (β=0.26, p=4.8×10⁻⁵). Variance component analysis showed ACR heritability of h²=0.20 and positive genetic correlation with HMW adiponectin (ρg=0.38, p=0.04), suggesting ADIPOQ variants modulate albuminuria levels.

Traits studied:Albuminuria (albumin-creatinine ratio)HMW adiponectin levels
PubMedDOIMetascience Observatory

About ARL15

Predicted to enable GTP binding activity and GTPase activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

View all ARL15 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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