rs432793
This variant is located in the GRXCR2 gene.
▶ClinVar annotation
▶Research that mentions this SNP (1)
▶Genome-wide association study of antipsychotic-induced parkinsonism severity among schizophrenia patientsAssociationN=397Ana Alkelai et al.(2009)· Psychopharmacology
A pharmacogenomic GWAS of 397 schizophrenia patients from the CATIE trial identified genetic variants associated with antipsychotic-induced parkinsonism (AIP) severity. The most significant SNP was rs12476047 (P=3.13×10⁻⁶, OR=3.21) near FIGN; candidate genes included EBF1 (rs891903, P=4.06×10⁻⁵), NOVA1 (rs8006700, rs1950420), and RAPGEF5 (rs7804311). Although no SNPs reached genome-wide significance threshold (P<4.2×10⁻⁷), the study identified promising genetic candidates for AIP susceptibility.
About GRXCR2
This gene encodes a protein containing a glutaredoxin domain, which functions in protein S-glutathionylation. A mutation in this gene was found in a family with autoosomal recessive nonsyndromic sensorineural deafness-101. [provided by RefSeq, Jun 2014]
View all GRXCR2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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