rs4328821
▶GWAS Catalog Trait Associations (8)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (8)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
neutrophil percentage of granulocytes
Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)
Allele G
OR 0.17
p 2.0e-184
N 170,672
Large GWAS
European
eosinophil percentage of granulocytes
Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)
Allele G
OR 0.15
p 6.0e-153
N 170,536
Large GWAS
European
eosinophil percentage of leukocytes
Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)
Allele G
OR 0.15
p 2.0e-145
N 172,378
Large GWAS
European
basophil count, eosinophil count
Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)
Allele G
OR 0.14
p 5.0e-138
N 171,771
Large GWAS
European
eosinophil count
Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)
Allele G
OR 0.13
p 4.0e-115
N 172,275
Large GWAS
European
Kachuri L et al. “Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia.” American Journal of Human Genetics 108(10):1823-1835 (2021)
Allele G
OR —
p 1.0e-101
N 234,763
Large GWAS
European
Jain D et al. “Genome-wide association of white blood cell counts in Hispanic/Latino Americans: the Hispanic Community Health Study/Study of Latinos.” Human Molecular Genetics 26(6):1193-1204 (2017)
Allele G
OR 0.06
p 1.0e-8
N 11,809
Large GWAS
Hispanic or Latin American
Okada Y et al. “Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.” Plos Genetics 7(6):e1002067 (2011)
Allele G
OR 0.10
p 3.0e-17
N 8,794
Large GWAS
East Asian
neutrophil percentage of leukocytes
Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)
Allele G
OR 0.09
p 5.0e-50
N 171,542
Large GWAS
European
basophil count
Okada Y et al. “Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.” Plos Genetics 7(6):e1002067 (2011)
Allele A
OR 0.16
p 5.0e-40
N 8,794
Large GWAS
East Asian
Nalls MA et al. “Multiple loci are associated with white blood cell phenotypes.” Plos Genetics 7(6):e1002113 (2011)
Allele A
OR 0.01
p 4.0e-13
N 19,509
Large GWAS
European
Jain D et al. “Genome-wide association of white blood cell counts in Hispanic/Latino Americans: the Hispanic Community Health Study/Study of Latinos.” Human Molecular Genetics 26(6):1193-1204 (2017)
Allele A
OR 0.07
p 1.0e-20
N 11,809
Large GWAS
Hispanic or Latin American
eosinophil measurement
Akbari P et al. “A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology.” Nature Communications 14(1):5023 (2023)
Allele G
OR 0.11
p 2.0e-16
N 29,084
Large GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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