rs445114

This is a intron variant variant in the CASC8 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

prostate carcinoma

Gudmundsson J et al. “Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility.” Nature Genetics 41(10):1122-6 (2009)
Allele T
OR 1.14
p 5.0e-10
N 37,350
Large GWAS
European
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Research that mentions this SNP (2)

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Associations of prostate cancer risk variants with disease aggressiveness: results of the NCI-SPORE Genetics Working Group analysis of 18,343 cases
AssociationN=18,343Brian T. Helfand et al.(2015)· Human Genetics

A case-case association study of 18,343 prostate cancer patients (16,515 European, 1,828 African-American) evaluating 36 validated PC-risk SNPs found that rs2735839 (G allele) on chromosome 19q13 in the KLK3 gene was significantly and inversely associated with aggressive disease and high Gleason scores in both populations (p = 9.343 × 10⁻⁸ overall, p = 1.042 × 10⁻⁵ European, p = 2.0 × 10⁻⁴ African-American).

Traits studied:Gleason scoreProstate cancer aggressivenessProstate cancer high-grade disease
PubMedDOIMetascience Observatory
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Meta‐analysis of genome‐wide and replication association studies on prostate cancer
AssociationN=916Hong Liu et al.(2011)· The Prostate

A case-control study of 489 prostate cancer cases and 427 controls in a New Zealand Caucasian population examined 15 chromosome 8q24 SNPs. Four SNPs showed statistically significant associations with prostate cancer risk: rs10086908 (T allele, OR=1.64), rs16901979 (A allele, OR=2.58), rs1447295 (A allele, OR=1.70), and rs4242382 (A allele, OR=1.60). A weighted genetic risk score based on all 15 SNPs was significantly associated with prostate cancer risk (OR=1.10), with smoking contributing additional risk.

Traits studied:Prostate cancer
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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