rs4460629

This is a intergenic variant variant.

▶

GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

magnesium measurement

Corre T et al. “Genome-Wide Meta-Analysis Unravels Interactions between Magnesium Homeostasis and Metabolic Phenotypes.” Journal of the American Society of Nephrology : Jasn 29(1):335-348 (2018)
Allele T
OR 0.14
p 4.0e-14
N 7,976
Meta-analysis
European

biological sex

Pirastu N et al. “Genetic analyses identify widespread sex-differential participation bias.” Nature Genetics 53(5):663-671 (2021)
Allele T
OR 0.01
p 5.0e-10
N 2,462,132
Large GWAS
European
▶

Research that mentions this SNP (1)

▶
G‐A variant in miR‐200c binding site of EFNA1 alters susceptibility to gastric cancer
MethodsN=5,542Yingfei Li et al.(2014)· Molecular Carcinogenesis

Pathway analysis of a gastric cancer GWAS dataset using ICSNPathway identified 7 candidate SNPs (rs4745, rs12904, rs1801019, rs364897, rs11187870, rs2274223, rs3765524) in 4 genes (EFNA1, UMPS, GBA, PLCE1) and 12 biological pathways. Four hypothetical mechanisms were proposed: ephrin receptor binding via EFNA1, pyrimidine metabolism via UMPS, cyanoamino acid metabolism via GBA, and cell growth/lipid biosynthesis via PLCE1.

Traits studied:Gastric cancer
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…