rs447372

This is a intron variant variant in the DKK2 gene.

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Research that mentions this SNP (1)

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Association of 12 polymorphic variants conferring genetic risk to lung cancer in Indian population: An extensive meta‐analysis
Meta-analysisN=19,556Debmalya Sengupta et al.(2017)· Environmental and Molecular Mutagenesis

A comprehensive meta-analysis of 50 case-control studies from the Indian subcontinent identified genetic variants modifying lung cancer risk, finding FDR-corrected associations for rs3547/XRCC1 (OR=1.83-2.72) and rs1048943/CYP1A1 (OR=2.07). The rs1048943/CYP1A1 variant showed strongest associations with adenocarcinoma (OR=3.38) and squamous cell carcinoma (OR=3.53) with significant effect modification by smoking status. Global meta-analysis confirmed rs1048943/CYP1A1 association across world populations (OR=1.22, p=0.01).

Traits studied:Lung adenocarcinomaLung cancerSmall cell lung carcinomaSquamous cell carcinoma
PubMedDOIMetascience Observatory

About DKK2

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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