rs4508917
This is a upstream gene variant variant in the ART3 gene.
▶Research that mentions this SNP (1)
▶The effects of CXCL10 polymorphisms on COPD susceptibilityAssociationN=968Yan Wang et al.(2018)· Molecular Genetics and Genomics
Case-control study of 480 COPD cases and 488 controls examining CXCL10 gene polymorphisms in a Chinese Han population. The T allele of rs56061981 was significantly associated with reduced COPD risk (OR=0.344, 95% CI 0.223-0.531, p<0.001), while the G allele of rs56316945 was associated with increased COPD risk (OR=2.232, 95% CI 1.491-3.339, p<0.001). rs56316945 was also associated with severity of pulmonary function in COPD patients.
About ART3
This gene encodes an arginine-specific ADP-ribosyltransferase. The encoded protein catalyzes a reversible reaction which modifies proteins by the addition or removal of ADP-ribose to an arginine residue to regulate the function of the modified protein. An ADP-ribosyltransferase pseudogene is located on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
View all ART3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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