rs4535211
This is a intron variant variant in the PLCL2 gene.
▶Research that mentions this SNP (1)
▶Rheumatoid arthritis risk allele PTPRC is also associated with response to anti–tumor necrosis factor α therapyAssociationN=1,283Cui J. et al.(2010)· Arthritis & Rheumatism
This multi-cohort genetic association study of 1,283 RA patients found that the PTPRC/CD45 gene variant rs10919563 (G allele) is associated with favorable response to anti-TNF therapy (OR 0.55, P=0.0001). Of 31 established RA risk alleles tested, only PTPRC reached genome-wide significance for therapy response, with stronger associations in autoantibody-positive patients (OR 0.55, 95% CI 0.39-0.76) compared to seronegative patients.
About PLCL2
Enables GABA receptor binding activity. Predicted to be involved in several processes, including gamma-aminobutyric acid signaling pathway; negative regulation of cold-induced thermogenesis; and phosphatidylinositol-mediated signaling. Predicted to act upstream of or within B cell proliferation involved in immune response; B-1a B cell differentiation; and negative regulation of B cell receptor signaling pathway. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
View all PLCL2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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