rs4561177
This is a upstream gene variant variant in the ZC3H12C gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
psoriasis
Tsoi LC et al. “Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.” Nature Genetics 44(12):1341-8 (2012)
Allele A
OR 1.14
p 8.0e-13
N 33,394
Large GWAS
European
Liu S et al. “Novel genetic insight for psoriasis: integrative genome-wide analyses in 863 080 individuals and proteome-wide Mendelian randomization.” Briefings in Bioinformatics 26(1) (2024)
Allele A
OR 0.09
p 4.0e-9
N 863,080
Large GWAS
European
psoriasis, type 2 diabetes mellitus
Patrick MT et al. “Causal Relationship and Shared Genetic Loci between Psoriasis and Type 2 Diabetes through Trans-Disease Meta-Analysis.” The Journal of Investigative Dermatology 141(6):1493-1502 (2021)
Allele A
OR 1.07
p 4.0e-10
N 925,490
Meta-analysisLarge GWAS
European
psoriasis vulgaris
Stuart PE et al. “Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.” American Journal of Human Genetics 97(6):816-36 (2015)
Allele A
OR 1.14
p 9.0e-9
N 8,941
Large GWAS
European
About ZC3H12C
Predicted to enable RNA endonuclease activity and mRNA binding activity. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
View all ZC3H12C variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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