rs458806
This variant is located in the REV3L gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
social inhibition quality, attention deficit hyperactivity disorder, substance abuse
▶Research that mentions this SNP (1)
▶“The Heidelberg Five” personality dimensions: Genome‐wide associations, polygenic risk for neuroticism, and psychopathology 20 years after assessmentAssociationN=481Urs Heilbronner et al.(2021)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
This study evaluated the use of polygenic scores (PGS) based on 10 top SNPs from European GWAS meta-analysis of antisocial behavior to predict liability to severe criminal behavior (homicide) in a Russian cohort of 227 offenders and 254 controls. A PGS based on rs993137 (CADM2), rs458806 (REV3L), rs11720703 (FOXP1), and rs1476535 (FOXP2) explained 1.5% of variance in liability to antisocial behavior, while the combined genetic model with social factors (traumatic brain injury, chronic disease, tobacco smoking) explained up to 21.2% of variance (p = 2 × 10⁻¹³), demonstrating that social factors have substantially greater predictive impact than genetic variants alone.
About REV3L
The protein encoded by this gene represents the catalytic subunit of DNA polymerase zeta, which functions in translesion DNA synthesis. The encoded protein can be found in mitochondria, where it protects DNA from damage. Defects in this gene are a cause of Mobius syndrome. [provided by RefSeq, Jan 2017]
View all REV3L variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…