rs4630220

▶

GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

white matter hyperintensity measurement

Persyn E et al. “Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants.” Nature Communications 11(1):2175 (2020)

Allele A

OR 7.24

p 1.0e-14

N 45,204

Large GWAS

multi-ancestry

Sargurupremraj M et al. “Cerebral small vessel disease genomics and its implications across the lifespan.” Nature Communications 11(1):6285 (2020)

Allele A

OR 0.05

p 2.0e-13

N 48,524

Large GWAS

multi-ancestry

Zhukovsky P et al. “Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression.” Nature Communications 15(1):5207 (2024)

Allele A

OR 5.98

p 2.0e-9

N 30,708

Large GWAS

European

hypertension, white matter hyperintensity measurement

Sargurupremraj M et al. “Cerebral small vessel disease genomics and its implications across the lifespan.” Nature Communications 11(1):6285 (2020)

Allele G

OR —

p 3.0e-13

N 48,524

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…