rs4630591
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Parkinson disease
Doostparast Torshizi A et al. “Proteogenomic network analysis reveals dysregulated mechanisms and potential mediators in Parkinson's disease.” Nature Communications 15(1):6430 (2024)
Allele T
OR 0.25
p 1.0e-18
N 539,017
Large GWAS
European
feeling "fed-up" measurement
Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele T
OR 8.54
p 1.0e-17
N 374,971
Large GWAS
European
cortical thickness
Smith SM et al. “An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank.” Nature Neuroscience 24(5):737-745 (2021)
Allele T
OR 0.10
p 5.0e-15
N 21,282
Major Consortium StudyLarge GWAS
European
Zhukovsky P et al. “Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression.” Nature Communications 15(1):5207 (2024)
Allele T
OR —
p 5.0e-13
N 34,532
Large GWAS
European
cognitive domain measurement
Schoeler T et al. “Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.” Nature Communications 16(1):4524 (2025)
Allele C
OR 0.03
p 3.0e-12
N 158,996
Large GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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