rs4632532

This is a intergenic variant variant.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

BMI-adjusted adiponectin measurement

Spracklen CN et al. “Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences.” Plos Genetics 16(9):e1009019 (2020)
Allele C
OR 0.13
p 2.0e-17
N 9,262
Large GWAS
European
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Research that mentions this SNP (2)

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The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents
AssociationN=703Laura J. Rasmussen-Torvik et al.(2009)· Human Genetics

This case-control association study examined 41 tag and candidate SNPs in the adiponectin (ADIPOQ) and its receptor genes (ADIPOR1, ADIPOR2) in relation to insulin sensitivity measured by euglycemic clamp in 584 white and 119 African American adolescents and their parents (n=703 total). One SNP in ADIPOQ (rs822393, p=0.0034) reached corrected significance threshold in whites and accounted for 1.9% of variance in insulin sensitivity; four additional ADIPOQ SNPs (rs4632532, rs266729, rs182052, rs7649121) showed suggestive associations (p<0.05). Two SNPs in ADIPOR1 showed suggestive associations in African Americans. The results suggest genetic variants in adiponectin pathway genes influence insulin sensitivity, with age potentially modifying the effect.

Traits studied:Insulin resistanceInsulin sensitivityObesity
PubMedDOIMetascience Observatory
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Association between variants in the genes for adiponectin and its receptors with insulin resistance syndrome (IRS)-related phenotypes in Mexican Americans
AssociationN=439Richardson DK et al.(2006)· Diabetologia

Candidate gene association study in 439 Mexican Americans examining variants in ADIPOQ, ADIPOR1, and ADIPOR2 genes and insulin resistance syndrome traits. ADIPOQ variants (rs4632532, rs266729) were associated with BMI, fasting insulin, and skinfold thickness. ADIPOR1 rs7539542 was associated with BMI and waist circumference. Notably, 14 ADIPOR2 SNPs were associated with fasting triglycerides, with rs10848569, rs929434, rs3809266, and rs12342 showing strongest associations (p<0.0004) and demonstrating that rs929434 explains 47% of previously detected linkage signal.

Traits studied:Body mass indexFasting HDL cholesterolFasting insulinFasting leptinFasting plasma glucoseFasting triglyceridesHOMA-S (insulin sensitivity)HOMA-β (β-cell function)Insulin resistance syndromeSum of skin fold thicknessType 2 diabetesWaist circumference
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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