rs4646251

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

N-acetylputrescine measurement

Feofanova EV et al. “Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.” Nature Communications 14(1):3111 (2023)
Allele G
OR 0.40
p 9.0e-40
N 9,182
Large GWAS
multi-ancestry
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Research that mentions this SNP (1)

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No association between apolipoprotein E or N‐Acetyltransferase 2 gene polymorphisms and age‐related hearing loss
AssociationN=265Piers Dawes et al.(2015)· The Laryngoscope

A candidate gene association study of 265 elderly Caucasian volunteers from the UK found no significant associations between NAT2 or APOE gene polymorphisms and age-related hearing loss (ARHL) using haplotype tagging SNP analysis. Linear regression analysis of 13 NAT2 htSNPs (including rs1799930/NAT2*6A) and APOE ε4 allele presence showed no significant associations (P > 0.05) with three hearing phenotypes (severity, slope, concavity), and epistasis analysis revealed no gene-gene interaction between these loci.

Traits studied:Age-related hearing lossPresbycusis
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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